Predictive Factors of Response to Mineralocorticoid Receptor Antagonists in Nonresolving Central Serous Chorioretinopathy

Am J Ophthalmol. 2019 Feb;198:80-87. doi: 10.1016/j.ajo.2018.09.034. Epub 2018 Oct 9.


Purpose: To assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) in the treatment of nonresolving central serous chorioretinopathy (CSC) and to identify factors that are predictive of treatment response.

Design: Retrospective, multicenter, noncomparative, interventional case series.

Methods: Clinical and imaging data from consecutive patients with nonresolving CSC treated with eplerenone or spironolactone for 3 to 6 months between 2012 and 2016 were reviewed. Outcome measures included the resolution of foveal subretinal detachment (SRD), changes in SRD height, central macular thickness, subfoveal choroidal thickness, best corrected visual acuity, and the occurrence of adverse events assessed at 3 and 6 months. The response to treatment was defined by a decrease by >50% in SRD height under treatment. Comparisons between responder and nonresponder groups were performed using univariate and multivariate regression analyses to identify factors that were predictive of treatment response.

Results: Fifty-nine patients (64 eyes) were included. The mean SRD height and central macular thickness significantly decreased while the mean best corrected visual acuity significantly improved at 3 and 6 months. The mean subfoveal choroidal thickness significantly decreased at 3 months. Among the 64 eyes included, 67.2% responded to treatment, among which 38.3% and 40.5% had a complete resolution of the foveal SRD at 3 and 6 months, respectively. Baseline subfoveal choroidal thickness was the only factor associated with a treatment response in the multivariate analysis.

Conclusion: Our study suggests that MRA could be a safe and effective treatment in patients with nonresolving CSC. MRA treatment is more effective in cases with a thicker baseline choroid.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Central Serous Chorioretinopathy / diagnostic imaging
  • Central Serous Chorioretinopathy / drug therapy*
  • Choroid / diagnostic imaging
  • Choroid / pathology
  • Eplerenone / therapeutic use*
  • Female
  • Fluorescein Angiography
  • Humans
  • Male
  • Middle Aged
  • Mineralocorticoid Receptor Antagonists / therapeutic use*
  • Multimodal Imaging
  • Retina / diagnostic imaging
  • Retina / pathology
  • Retrospective Studies
  • Spironolactone / therapeutic use*
  • Tomography, Optical Coherence / methods
  • Treatment Outcome
  • Visual Acuity / physiology


  • Mineralocorticoid Receptor Antagonists
  • Spironolactone
  • Eplerenone