Understanding molecular mechanisms of disease through spatial proteomics

Curr Opin Chem Biol. 2019 Feb;48:19-25. doi: 10.1016/j.cbpa.2018.09.016. Epub 2018 Oct 9.


Mammalian cells are organized into different compartments that separate and facilitate physiological processes by providing specialized local environments and allowing different, otherwise incompatible biological processes to be carried out simultaneously. Proteins are targeted to these subcellular locations where they fulfill specialized, compartment-specific functions. Spatial proteomics aims to localize and quantify proteins within subcellular structures.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cellular Structures / chemistry
  • Cellular Structures / metabolism
  • Cellular Structures / pathology
  • Humans
  • Protein Interaction Mapping / methods
  • Protein Interaction Maps*
  • Proteins / analysis*
  • Proteins / metabolism*
  • Proteomics / methods*


  • Proteins