Cardiovascular Implications of Sphingomyelin Presence in Biological Membranes

doi:10.15420/ecr.2017:20:3

Review

. 2018 Aug;13(1):42-45.

doi: 10.15420/ecr.2017:20:3.

Cardiovascular Implications of Sphingomyelin Presence in Biological Membranes

Petros Kikas¹, George Chalikias¹, Dimitrios Tziakas¹

Affiliations

PMID: 30310470
PMCID: PMC6159463
DOI: 10.15420/ecr.2017:20:3

Review

Cardiovascular Implications of Sphingomyelin Presence in Biological Membranes

Petros Kikas et al. Eur Cardiol. 2018 Aug.

. 2018 Aug;13(1):42-45.

doi: 10.15420/ecr.2017:20:3.

Authors

Petros Kikas¹, George Chalikias¹, Dimitrios Tziakas¹

Affiliation

¹ Democritus University of Thrace Alexandroupolis, Greece.

PMID: 30310470
PMCID: PMC6159463
DOI: 10.15420/ecr.2017:20:3

Abstract

Sphingomyelin (SM) is a type of sphingolipid found within plasma, cellular membranes and plasma lipoproteins. Here we highlight the basic biochemical features of SMs and their role in biological membranes. We further discuss evidence of the association between SM and cardiovascular diseases such as atherosclerosis, valvular disease, heart failure and diabetes mellitus.

Keywords: Sphingomyelin; cardiovascular implications; sphingolipids.

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Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare.

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References

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[1] Breslow DK, Weissman JS. Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell. 2010;40:267–79. doi: 10.1016/j.molcel.2010.10.005. - DOI - PMC - PubMed

[2] Breslow DK, Weissman JS. Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell. 2010;40:267–79. doi: 10.1016/j.molcel.2010.10.005. - DOI - PMC - PubMed

[3] Barenholz Y, Thompson TE. Sphingomyelins in bilayers and biological membranes. Biochim Biophys Acta. 1980;604:129–58. doi: 10.1016/0005-2736(80)90572-6. - DOI - PubMed

[4] Barenholz Y, Thompson TE. Sphingomyelins in bilayers and biological membranes. Biochim Biophys Acta. 1980;604:129–58. doi: 10.1016/0005-2736(80)90572-6. - DOI - PubMed

[5] Slotte JP. Molecular properties of various structurally defined sphingomyelins -- correlation of structure with function. Prog Lipid Res. 2013;52:206–19. doi: 10.1016/j.plipres.2012.12.001. - DOI - PubMed

[6] Slotte JP. Molecular properties of various structurally defined sphingomyelins -- correlation of structure with function. Prog Lipid Res. 2013;52:206–19. doi: 10.1016/j.plipres.2012.12.001. - DOI - PubMed

[7] Thudicum JL. London: Bailliere, Tindall and Cox,: 1884. A treatise on the chemical constitution of brain.

[8] Thudicum JL. London: Bailliere, Tindall and Cox,: 1884. A treatise on the chemical constitution of brain.

[9] Pick L, Bielschowsky M. Verhandlungen ärztlicher gesellschaften. Klin Wochenschr. 1927;6:1631–7. doi: 10.1007/BF01467780. [in German]. - DOI

[10] Pick L, Bielschowsky M. Verhandlungen ärztlicher gesellschaften. Klin Wochenschr. 1927;6:1631–7. doi: 10.1007/BF01467780. [in German]. - DOI

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Cardiovascular Implications of Sphingomyelin Presence in Biological Membranes

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Cardiovascular Implications of Sphingomyelin Presence in Biological Membranes

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