Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes

doi:10.1099/mic.0.000724

. 2018 Nov;164(11):1345-1347.

doi: 10.1099/mic.0.000724. Epub 2018 Oct 12.

Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes

Mark J Taylor¹, Seth R Bordenstein^{2

3

4

5}, Barton Slatko⁶

Affiliations

¹ 1Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
² 2Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
³ 3Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA.
⁴ 4Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University, Nashville, TN, USA.
⁵ 5Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
⁶ 6New England Biolabs, Inc., 240 County Road, Ipswich, MA 01938, USA.

PMID: 30311871
PMCID: PMC7008210
DOI: 10.1099/mic.0.000724

Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes

Mark J Taylor et al. Microbiology (Reading). 2018 Nov.

. 2018 Nov;164(11):1345-1347.

doi: 10.1099/mic.0.000724. Epub 2018 Oct 12.

Authors

Mark J Taylor¹, Seth R Bordenstein^{2

3

4

5}, Barton Slatko⁶

Affiliations

¹ 1Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
² 2Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
³ 3Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA.
⁴ 4Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University, Nashville, TN, USA.
⁵ 5Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
⁶ 6New England Biolabs, Inc., 240 County Road, Ipswich, MA 01938, USA.

PMID: 30311871
PMCID: PMC7008210
DOI: 10.1099/mic.0.000724

Abstract

Wolbachia is the most widespread genus of endosymbiotic bacteria in the animal world, infecting a diverse range of arthropods and nematodes. A broad spectrum of associations from parasitism to mutualism occur, with a tendency to drive reproductive manipulation or influence host fecundity to spread infection through host populations. These varied effects of Wolbachia are exploited for public health benefits. Notably, the protection of insect hosts from viruses is being tested as a potential control strategy for human arboviruses, and the mutualistic relationship with filarial nematodes makes Wolbachia a target for antibiotic therapy of human and veterinary nematode diseases.

Keywords: Wolbachia.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Cited by

Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila.
Shropshire JD, Bordenstein SR. Shropshire JD, et al. PLoS Genet. 2019 Jun 26;15(6):e1008221. doi: 10.1371/journal.pgen.1008221. eCollection 2019 Jun. PLoS Genet. 2019. PMID: 31242186 Free PMC article.
The Wolbachia mobilome in Culex pipiens includes a putative plasmid.
Reveillaud J, Bordenstein SR, Cruaud C, Shaiber A, Esen ÖC, Weill M, Makoundou P, Lolans K, Watson AR, Rakotoarivony I, Bordenstein SR, Eren AM. Reveillaud J, et al. Nat Commun. 2019 Mar 5;10(1):1051. doi: 10.1038/s41467-019-08973-w. Nat Commun. 2019. PMID: 30837458 Free PMC article.
Aspartyl Protease Inhibitors as Anti-Filarial Drugs.
Beld L, Jung H, Bulman CA, Rosa BA, Fischer PU, Janetka JW, Lustigman S, Sakanari JA, Mitreva M. Beld L, et al. Pathogens. 2022 Jun 18;11(6):707. doi: 10.3390/pathogens11060707. Pathogens. 2022. PMID: 35745561 Free PMC article.
Bacterial Community Survey of Wolbachia-Infected Parthenogenetic Parasitoid Trichogramma pretiosum (Hymenoptera: Trichogrammatidae) Treated with Antibiotics and High Temperature.
Guo W, Zhang M, Lin L, Zeng C, Zhang Y, He X. Guo W, et al. Int J Mol Sci. 2023 May 8;24(9):8448. doi: 10.3390/ijms24098448. Int J Mol Sci. 2023. PMID: 37176154 Free PMC article.
Grappling with the tick microbiome.
Narasimhan S, Swei A, Abouneameh S, Pal U, Pedra JHF, Fikrig E. Narasimhan S, et al. Trends Parasitol. 2021 Aug;37(8):722-733. doi: 10.1016/j.pt.2021.04.004. Epub 2021 May 4. Trends Parasitol. 2021. PMID: 33962878 Free PMC article. Review.

See all "Cited by" articles

References

1. Werren JH, Baldo L, Clark ME. Wolbachia: master manipulators of invertebrate biology. Nat Rev Microbiol. 2008;6:741–751. doi: 10.1038/nrmicro1969. - DOI - PubMed
1. Lepage DP, Metcalf JA, Bordenstein SR, On J, Perlmutter JI, et al. Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. 2017;543:243–247. doi: 10.1038/nature21391. - DOI - PMC - PubMed
1. Hoffmann AA, Montgomery BL, Popovici J, Iturbe-Ormaetxe I, Johnson PH, et al. Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature. 2011;476:454–457. doi: 10.1038/nature10356. - DOI - PubMed
1. Tamarozzi F, Halliday A, Gentil K, Hoerauf A, Pearlman E, et al. Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment. Clin Microbiol Rev. 2011;24:459–468. doi: 10.1128/CMR.00057-10. - DOI - PMC - PubMed
1. Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA. Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis. Parasitology. 2014;141:119–127. doi: 10.1017/S0031182013001108. - DOI - PMC - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources

[1] Werren JH, Baldo L, Clark ME. Wolbachia: master manipulators of invertebrate biology. Nat Rev Microbiol. 2008;6:741–751. doi: 10.1038/nrmicro1969. - DOI - PubMed

[2] Werren JH, Baldo L, Clark ME. Wolbachia: master manipulators of invertebrate biology. Nat Rev Microbiol. 2008;6:741–751. doi: 10.1038/nrmicro1969. - DOI - PubMed

[3] Lepage DP, Metcalf JA, Bordenstein SR, On J, Perlmutter JI, et al. Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. 2017;543:243–247. doi: 10.1038/nature21391. - DOI - PMC - PubMed

[4] Lepage DP, Metcalf JA, Bordenstein SR, On J, Perlmutter JI, et al. Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. 2017;543:243–247. doi: 10.1038/nature21391. - DOI - PMC - PubMed

[5] Hoffmann AA, Montgomery BL, Popovici J, Iturbe-Ormaetxe I, Johnson PH, et al. Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature. 2011;476:454–457. doi: 10.1038/nature10356. - DOI - PubMed

[6] Hoffmann AA, Montgomery BL, Popovici J, Iturbe-Ormaetxe I, Johnson PH, et al. Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature. 2011;476:454–457. doi: 10.1038/nature10356. - DOI - PubMed

[7] Tamarozzi F, Halliday A, Gentil K, Hoerauf A, Pearlman E, et al. Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment. Clin Microbiol Rev. 2011;24:459–468. doi: 10.1128/CMR.00057-10. - DOI - PMC - PubMed

[8] Tamarozzi F, Halliday A, Gentil K, Hoerauf A, Pearlman E, et al. Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment. Clin Microbiol Rev. 2011;24:459–468. doi: 10.1128/CMR.00057-10. - DOI - PMC - PubMed

[9] Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA. Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis. Parasitology. 2014;141:119–127. doi: 10.1017/S0031182013001108. - DOI - PMC - PubMed

[10] Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA. Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis. Parasitology. 2014;141:119–127. doi: 10.1017/S0031182013001108. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes

Affiliations

Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources