Serum ferritin level as an early indicator of metabolic dysregulation in young obese adults - a cross-sectional study

Can J Physiol Pharmacol. 2018 Dec;96(12):1255-1260. doi: 10.1139/cjpp-2018-0433. Epub 2018 Oct 12.


The aim of this study was to investigate the relationship between serum ferritin level and antioxidative status and metabolic dysregulation in young adult obese population. This cross-sectional study included 300 subjects of either sex, grouped as obese and non-obese subjects. The body mass index, total iron binding capacity, fasting blood glucose, superoxide dismutase activity, and levels of serum ferritin, iron, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, glutathione, and vitamin C were estimated. Analysis showed a significant alteration in all the parameters in obese adults. The correlation of ferritin level and body mass index showed a positive correlation (r = -0.81, p < 0.001, respectively) with levels of fasting blood glucose, superoxide dismutase, total cholesterol, low-density lipoprotein cholesterol, and triglyceride in obese individuals, whereas an insignificant correlation with vitamin C and glutathione level was observed in obese individuals. The significant positive correlation of ferritin level with the metabolic parameters and some antioxidative parameters in obese individuals signifies the development of metabolic disorders. Therefore, estimation of serum ferritin level will be an important early indicator for the risk of developing metabolic disorders in young adults.

Keywords: capacité de liaison du fer totale; dysrégulation métabolique; ferritine sérique; glutathion; glutathione; metabolic dysregulation; obesity; obésité; serum ferritin; superoxide dismutase; superoxyde dismutase; total iron binding capacity; vitamin C; vitamine C.

MeSH terms

  • Adolescent
  • Adult
  • Antioxidants / metabolism
  • Ascorbic Acid / metabolism
  • Blood Glucose / metabolism
  • Body Mass Index
  • Cholesterol / blood
  • Cross-Sectional Studies
  • Female
  • Ferritins / blood*
  • Glutathione / metabolism
  • Humans
  • Iron / blood
  • Male
  • Metabolic Diseases / blood*
  • Metabolic Diseases / metabolism
  • Metabolic Diseases / pathology
  • Obesity / blood*
  • Obesity / metabolism
  • Obesity / pathology
  • Superoxide Dismutase / metabolism
  • Young Adult


  • Antioxidants
  • Blood Glucose
  • Ferritins
  • Cholesterol
  • Iron
  • Superoxide Dismutase
  • Glutathione
  • Ascorbic Acid