Effect of phosphorus intake in total parenteral nutrition infusates in premature neonates

J Pediatr. 1987 Apr;110(4):586-90. doi: 10.1016/s0022-3476(87)80558-9.


Phosphorus intake was evaluated in 27 appropriate weight for gestational age, critically ill neonates who required total parenteral nutrition for 2 weeks. All received approximately 30 mg/kg/d elemental calcium. The low P intake group (1.01 mmol/kg/d, 30 mg/kg/d) showed signs of phosphate depletion: hypercalciuria, hypophosphatemia, and absence of phosphaturia. The high P intake group (1.67 mmol/kg/d, 50 mg/kg/d) did not have signs of P depletion; however, they had high urinary cyclic adenosine monophosphate excretion and marked phosphaturia, suggesting secondary hyperparathyroidism. The moderate P intake group (1.34 mmol/kg/d, 40 mg/kg/d) had evidence of neither phosphate depletion nor secondary hyperparathyroidism. This phosphorus dose appears to be appropriate for the very sick, poorly growing infant receiving total parenteral nutrition.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / metabolism
  • Cyclic AMP / urine
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / blood
  • Infant, Premature, Diseases / therapy*
  • Infant, Premature, Diseases / urine
  • Male
  • Parenteral Nutrition, Total*
  • Phosphorus / administration & dosage*
  • Phosphorus / metabolism


  • Phosphorus
  • Cyclic AMP
  • Calcium