Microcapsule of sweet orange essential oil changes gut microbiota in diet-induced obese rats

Biochem Biophys Res Commun. 2018 Nov 10;505(4):991-995. doi: 10.1016/j.bbrc.2018.10.035. Epub 2018 Oct 9.


Obesity is associated with the changes in gut microbiota. The aim of present study was to investigate the effects of sweet orange essential oil (SOEO) microcapsules on body weight and gut microbiota in obese rats induced by high-fat diet. By analyzing the body weight, fat rate and the sequence of cloned microbial small-subunit ribosomal RNA genes (16S rDNA) in rats fecal samples, we found that SOEO microcapsules decreased the body weight and increased the relative abundance of Bifidobacterium (genus-level) in gut microbiota. The analysis of endotoxin content proved that SOEO microcapsules protected gut barrier and decreased gut endotoxin levels by increasing the content of Bifidobacterium, then ameliorated low-grade inflammation, achieving the goal of losing weight. This might be the mechanism of SOEO microcapsules to lose body weight and provided a novel anti-obesity dietary supplement.

Keywords: 16S rDNA; Gut microbiota; Microcapsule; Obese rats; Sweet orange essential oil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Availability
  • Body Weight / drug effects
  • Capsules / chemistry
  • Citrus / chemistry*
  • Diet, High-Fat / adverse effects
  • Dietary Supplements
  • Endotoxins / blood
  • Gastrointestinal Microbiome / drug effects*
  • Male
  • Obesity / drug therapy*
  • Obesity / microbiology
  • Oils, Volatile / administration & dosage
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Solubility


  • Capsules
  • Endotoxins
  • Oils, Volatile