Inhibitory effects of bisdemethoxycurcumin on mast cell-mediated allergic diseases

Int Immunopharmacol. 2018 Dec;65:182-189. doi: 10.1016/j.intimp.2018.10.005. Epub 2018 Oct 10.

Abstract

Most allergic reactions are induced by mast cell activation. Mast cells play vital roles in the pathogenesis of allergic diseases. Bisdemethoxycurcumin (BDMC), a natural curcuminoid, has potential anti-allergic effects. Hence, we explored the effect of BDMC on mast cell-mediated allergic diseases. The study proved that BDMC suppresses β-hexosaminidase release, granule release, and membrane ruffling in monoclonal anti-2,4,6-dinitrophenyl-immunoglobulin (Ig) E/human serum albumin (DNP-IgE/HSA)-stimulated rat basophilic leukaemia cells (RBL-2H3 cells), and BDMC suppressed ovalbumin (OVA)-induced allergic rhinitis (AR) symptoms and OVA-specific IgE levels in AR mice. Furthermore, BDMC increased the survival of compound 48/80 anaphylaxis shock mice and elevated the decreased rectal temperature in OVA-induced active systemic anaphylaxis mice. These findings indicate that BDMC regulates the degranulation of mast cells, demonstrating its potential in the treatment of mast cell-induced allergic reactions.

Keywords: Allergic disease; Bisdemethoxycurcumin; Mast cell.

MeSH terms

  • Anaphylaxis / chemically induced
  • Anaphylaxis / drug therapy
  • Animals
  • Cell Line
  • Curcumin / analogs & derivatives*
  • Curcumin / pharmacology
  • Curcumin / therapeutic use
  • Diarylheptanoids
  • Hypersensitivity / prevention & control*
  • Male
  • Mast Cells / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin / toxicity
  • Rats
  • Rhinitis, Allergic / chemically induced
  • Rhinitis, Allergic / drug therapy
  • p-Methoxy-N-methylphenethylamine / toxicity

Substances

  • Diarylheptanoids
  • bis(4-hydroxycinnamoyl)methane
  • p-Methoxy-N-methylphenethylamine
  • Ovalbumin
  • Curcumin