The Emergence of Dihydroorotate Dehydrogenase (DHODH) as a Therapeutic Target in Acute Myeloid Leukemia

Expert Opin Ther Targets. 2018 Nov;22(11):893-898. doi: 10.1080/14728222.2018.1536748. Epub 2018 Oct 17.

Abstract

No abstract available

Keywords: Acute myeloid leukemia; Brequinar; DHODH; differentiation; metabolism; nucleotides; pyrimidines; therapeutic window.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / enzymology
  • Molecular Targeted Therapy
  • Oxidoreductases Acting on CH-CH Group Donors / antagonists & inhibitors*
  • Oxidoreductases Acting on CH-CH Group Donors / metabolism

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Oxidoreductases Acting on CH-CH Group Donors
  • dihydroorotate dehydrogenase