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, 27 (5), 1493-1501
eCollection

Ginger Attenuates Inflammation in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis

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Ginger Attenuates Inflammation in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis

Min Seo Kim et al. Food Sci Biotechnol.

Abstract

This study assessed the anti-inflammatory effect of ginger extract on colitis by 5% dextran sulfate sodium (DSS) in BALB/c mice. The mice were administered either distilled water or three doses of ginger extracts for 21 days. We evaluated the change in clinical and histopathological signs and cytokine and gene expression levels. Contrary to the DSS group, the ginger groups increased body weight and inhibited shortening of the colon. DAI values and colon injury in the ginger groups were lower than that in the DSS group. Ginger groups obviously inhibited the myeloperoxidase activity and cytokine and mRNA concentrations of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, but not of intestinal barrier proteins zonula occludens (ZO)-1, occludin, E-cadherin, mucin-1, and mucin-2 in colon tissues. Our results suggest the protective effect of ginger against DSS-induced colitis and that ginger could be utilized to prevent and treat irritable bowel disease.

Keywords: Colitis; Dextran sulfate sodium; Ginger; Inflammation; Inflammatory bowel disease.

Figures

Fig. 1
Fig. 1
Effect of ginger extracts on clinical symptoms and colon shortening in DSS-induced colitis. (A) Body weight was recorded simultaneously on the experimental days; (B) the score of disease activity index; (C) DSS-induced shortened colon was significantly ameliorated by ginger extracts; (D) representative colons of each group. (*p < 0.05 compared to the DSS group)
Fig. 2
Fig. 2
(A) Histopathological features of colons from BALB/c mice with 5% DSS-induced colitis. Hematoxylin and Eosin staining. Magnification 100× (bar = 100 mm), 200× (bar = 200 mm). Ginger extracts effectively attenuated (B) histopathological changes and increased (C) goblet cells in the colon with 5% DSS-induced colitis
Fig. 3
Fig. 3
Effect of ginger extracts on myeloperoxidase activity in the colon of DSS-induced BALB/c mice
Fig. 4
Fig. 4
Effect of ginger extracts on inflammatory cytokines and mRNA levels in the colon. (A) Concentration profile of IL-1β, IL-6, and TNF-α; (B) Relative mRNA expression profiles of IL-1β, IL-6, and TNF-α
Fig. 5
Fig. 5
Effect of ginger extracts on relative mRNA expression of tight junction proteins in the colon. Relative mRNA expression profiles of (A) ZO-1; (B) Occludin; (C) E-cadherin; (D) mucin-1; (E) mucin-2

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