Superhydrophobic silver film as a SERS substrate for the detection of uric acid and creatinine

Yudong Lu; Changji Wu; Ruiyun You; Yang Wu; Huiying Shen; Lanjin Zhu; Shangyuan Feng

doi:10.1364/BOE.9.004988

Superhydrophobic silver film as a SERS substrate for the detection of uric acid and creatinine

Biomed Opt Express. 2018 Sep 24;9(10):4988-4997. doi: 10.1364/BOE.9.004988. eCollection 2018 Oct 1.

Authors

Yudong Lu¹, Changji Wu¹, Ruiyun You¹, Yang Wu¹, Huiying Shen¹, Lanjin Zhu¹, Shangyuan Feng²

Affiliations

¹ College of Chemistry and Materials Science, Fujian Key Laboratory of Polymer Materials, Fujian Normal University, Fuzhou, Fujian 350007, China.
² Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350007, China.

Abstract

Superhydrophobic silver films were fabricated by silver-mirror reaction and surface functionalization with thiol. The thiol-functionalization significantly improved the hydrophobic property of the Ag films (AFS), and their contact angle values slightly increased with the extension of a thiol alkyl chain, reaching about 160°. The surface-enhanced Raman scattering (SERS) detection capacity of these films were investigated, and AFS-Dodec showed the best substrate for R6G molecule detection with the concentration limit of 10^-11 M. AFS functionalized with dodecanethiol (AFS-Dodec) was applied for the SERS detection of uric acid and creatinine, it exhibited good linear dependence relationship between the Raman intensity and analyte concentration in the concentration range of 5~1000 μM.