New antihypertensive medications and clinical implications

Best Pract Res Clin Anaesthesiol. 2018 Jun;32(2):223-235. doi: 10.1016/j.bpa.2018.06.013. Epub 2018 Aug 1.


Hypertension remains a global public health issue and is a leading preventable risk factor for many causes of mortality and morbidity. Although it is generally managed as an outpatient chronic disease, anaesthetists will inevitably encounter patients with hypertension, ranging from undiagnosed asymptomatic to chronic forms with end-organ damage(s). An understanding of perioperative management of anti-hypertensive pharmacotherapy is crucial. Although many drugs are familiar, new drug groups that have relevance for blood pressure control and perioperative care have evolved in recent years. This article also describes new antihypertensive agents currently available or under development that could impact perioperative management.

Keywords: hypertension; novel antihypertensives; perioperative management; pre-operative factors.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / administration & dosage*
  • Blood Pressure / drug effects*
  • Blood Pressure / physiology
  • Blood Pressure Determination / methods
  • Blood Pressure Determination / trends
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Hypertension / surgery
  • Perioperative Care / methods*
  • Perioperative Care / trends
  • Risk Factors


  • Antihypertensive Agents