Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury

doi:10.1007/s12265-018-9823-z

Review

. 2018 Oct;11(5):403-411.

doi: 10.1007/s12265-018-9823-z. Epub 2018 Oct 15.

Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury

Zhonghao Tao¹, Shihua Tan², Wen Chen¹, Xin Chen³

Affiliations

¹ Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, People's Republic of China.
² National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
³ Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, People's Republic of China. stevecx@njmu.edu.cn.

PMID: 30324254
DOI: 10.1007/s12265-018-9823-z

Review

Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury

Zhonghao Tao et al. J Cardiovasc Transl Res. 2018 Oct.

. 2018 Oct;11(5):403-411.

doi: 10.1007/s12265-018-9823-z. Epub 2018 Oct 15.

Authors

Zhonghao Tao¹, Shihua Tan², Wen Chen¹, Xin Chen³

Affiliations

¹ Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, People's Republic of China.
² National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
³ Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, People's Republic of China. stevecx@njmu.edu.cn.

PMID: 30324254
DOI: 10.1007/s12265-018-9823-z

Abstract

Despite advances in the prevention and therapeutic modalities of ischemic heart disease, morbidity and mortality post-infarction heart failure remain big challenges in modern society. Stem cell therapy is emerging as a promising therapeutic strategy. Stem cell homing, the ability of stem cells to find their destination, is receiving more attention. Identification of specific cues and understanding the signaling pathways that direct stem cells to targeted destination will improve stem cell homing efficiency. This review discusses the cellular and molecular mechanism of stem cell homing at length in the light of literature and analyzes the problem and considerations of this approach as a treatment strategy for the treatment of ischemic heart disease clinically.

Keywords: Homing; Stem cell; Therapy.

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[1] Int J Mol Med. 2012 Dec;30(6):1313-20 - PubMed

[2] Int J Mol Med. 2012 Dec;30(6):1313-20 - PubMed

[3] Exp Cell Res. 2010 Dec 10;316(20):3435-42 - PubMed

[4] Exp Cell Res. 2010 Dec 10;316(20):3435-42 - PubMed

[5] Mol Ther. 2015 Dec;23(12):1854-66 - PubMed

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[8] Tissue Eng. 2007 Aug;13(8):2063-71 - PubMed

[9] Int J Cardiol. 2006 Aug 10;111(2):202-8 - PubMed

[10] Int J Cardiol. 2006 Aug 10;111(2):202-8 - PubMed

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Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury

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Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury

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