Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review

Laryngoscope. 2018 Dec;128(12):2759-2761. doi: 10.1002/lary.27259. Epub 2018 Oct 16.


Head and neck cancers account for a significant proportion of reported malignancies in the United States; however, multiple concurrent primary malignancies from different sites are rare. We describe the case of a 44-year-old man simultaneously diagnosed with three independent head and neck malignancies (adenocarcinoma in minor salivary gland, papillary thyroid carcinoma, and acinic cell carcinoma) in the setting of Lynch syndrome. To our knowledge, this is the first case of multiple head and neck malignancies arising simultaneously from Lynch syndrome. This case highlights the need for diligent workup in patients with hereditary conditions that predispose to malignancies. Laryngoscope, 128:2759-2761, 2018.

Keywords: Head and neck cancer; Lynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC).

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Adult
  • Biopsy
  • Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis*
  • Humans
  • Male
  • Mouth Mucosa / pathology*
  • Neoplasm Staging*
  • Neoplasms, Multiple Primary*
  • Salivary Gland Neoplasms / diagnosis*