The prophylactic use of polyvinylpyridine-N-oxide (PVNO) in baboons exposed to quartz dust

Environ Res. 1987 Apr;42(2):469-81. doi: 10.1016/s0013-9351(87)80214-1.

Abstract

Twelve baboons were exposed to a quartz dust cloud. Four of these were also given polyvinylpyridine-N-oxide (PVNO) by aerosol and four received PVNO by aerosol and injection. A prophylactic effect was demonstrated during the course of treatment, but when treatment stopped the silicosis progressed to the same degree of severity as in the untreated animals.

MeSH terms

  • Animals
  • Collagen / analysis
  • Dust / adverse effects*
  • Liver / drug effects
  • Liver / physiology
  • Lung / analysis
  • Lung / pathology
  • Male
  • Papio
  • Polyvinylpyridine N-Oxide / blood
  • Polyvinylpyridine N-Oxide / pharmacology*
  • Polyvinyls / pharmacology*
  • Quartz / toxicity*
  • Silicon Dioxide / analysis
  • Silicon Dioxide / toxicity*
  • Silicosis / prevention & control*

Substances

  • Dust
  • Polyvinyls
  • Quartz
  • Silicon Dioxide
  • Collagen
  • Polyvinylpyridine N-Oxide