Firing Up Glycolysis: BCG Vaccination Effects on Type 1 Diabetes Mellitus

Trends Endocrinol Metab. 2018 Dec;29(12):813-814. doi: 10.1016/j.tem.2018.10.001. Epub 2018 Oct 13.

Abstract

In addition to the impact of Bacillus Calmette-Guerin (BCG) vaccination on antimicrobial host defence, a novel study reveals beneficial effects on glycaemic control in patients with long-standing type 1 diabetes mellitus (T1DM). These effects are ascribed to an accelerated glucose consumption in immune cells due to increased glycolysis and reduced oxidative phosphorylation.

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • BCG Vaccine / pharmacology*
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Glycolysis / drug effects*
  • Humans

Substances

  • Adjuvants, Immunologic
  • BCG Vaccine