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. 2019 Jan 8;47(D1):D128-D134.
doi: 10.1093/nar/gky960.

LncBook: A Curated Knowledgebase of Human Long Non-Coding RNAs

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Free PMC article

LncBook: A Curated Knowledgebase of Human Long Non-Coding RNAs

Lina Ma et al. Nucleic Acids Res. .
Free PMC article

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Abstract

Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number of known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating their complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), a curated knowledgebase of human lncRNAs that features a comprehensive collection of human lncRNAs and systematic curation of lncRNAs by multi-omics data integration, functional annotation and disease association. In the present version, LncBook houses a large number of 270 044 lncRNAs and includes 1867 featured lncRNAs with 3762 lncRNA-function associations. It also integrates an abundance of multi-omics data from expression, methylation, genome variation and lncRNA-miRNA interaction. Also, LncBook incorporates 3772 experimentally validated lncRNA-disease associations and further identifies a total of 97 998 lncRNAs that are putatively disease-associated. Collectively, LncBook is dedicated to the integration and curation of human lncRNAs as well as their associated data and thus bears great promise to serve as a valuable knowledgebase for worldwide research communities.

Figures

Figure 1.
Figure 1.
Workflow diagram of lncRNA curation and integration. The human lncRNAs in LncBook are compiled from (i) existing databases, (ii) novel RNA assemblies based on RNA-seq data analysis and (iii) published literature.
Figure 2.
Figure 2.
Screenshots of web pages for a lncRNA transcript. For example, HOTAIR is extensively annotated with an abundance of multi-omics data including (A) expression, (B) methylation, (C) variation, (D) interaction and the systematic curations of (E) function and (F) disease based on published literature.

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