Racheting Up Repair

Immunity. 2018 Oct 16;49(4):577-579. doi: 10.1016/j.immuni.2018.09.012.


In this issue of Immunity, Daniel et al. (2018a) demonstrate that the nuclear receptor PPARγ acts in a ligand-insensitive manner to impart transcriptional memory and enhanced functionality to IL-4 polarized macrophages. Their findings shed light on the mechanisms that control priming of the epigenome in response to inflammatory signals.

Publication types

  • Comment

MeSH terms

  • Epigenomics*
  • Ligands
  • Macrophages / immunology
  • PPAR gamma*


  • Ligands
  • PPAR gamma