HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis

Ho Min Kim; You-Me Kim

doi:10.1016/j.immuni.2018.09.021

HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis

Immunity. 2018 Oct 16;49(4):582-584. doi: 10.1016/j.immuni.2018.09.021.

Authors

Ho Min Kim¹, You-Me Kim²

Affiliations

¹ Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea. Electronic address: hm_kim@kaist.ac.kr.
² Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea. Electronic address: youmekim@kaist.ac.kr.

PMID: 30332623
DOI: 10.1016/j.immuni.2018.09.021

Abstract

Recognition of cytoplasmic lipopolysaccharide (LPS) by caspase-11 leads to pyroptosis and secretion of inflammatory mediators. In this issue of Immunity, Deng et al. (2018) report that high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into the cytoplasm and mediates pyroptosis.

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MeSH terms

Caspases
Endotoxins
HMGB1 Protein*
Humans
Lipopolysaccharides
Pyroptosis
Sepsis*

Substances

Endotoxins
HMGB1 Protein
Lipopolysaccharides
Caspases