Lineage Specifiers in Lung Cancer Are Ahead of Their TIME

Kelli A Connolly; Brittany Fitzgerald; Nikhil S Joshi

doi:10.1016/j.immuni.2018.10.004

Lineage Specifiers in Lung Cancer Are Ahead of Their TIME

Immunity. 2018 Oct 16;49(4):587-589. doi: 10.1016/j.immuni.2018.10.004.

Authors

Kelli A Connolly¹, Brittany Fitzgerald¹, Nikhil S Joshi²

Affiliations

¹ Yale University School of Medicine, Department of Immunobiology, New Haven, CT 06519, USA.
² Yale University School of Medicine, Department of Immunobiology, New Haven, CT 06519, USA. Electronic address: nikhil.joshi@yale.edu.

PMID: 30332625
DOI: 10.1016/j.immuni.2018.10.004

Abstract

The factors that shape the distinctive tumor-immune landscapes of various types and subtypes of cancer remain poorly understood. In this issue of Immunity, Mollaoglu et al. (2018) reveal a mechanistic link between the function of lineage specifiers SOX2 and NKX2-1 and the presence of neutrophils in the tumor-immune microenvironment of lung cancer.

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MeSH terms

Cell Differentiation
Humans
Lung Neoplasms*
SOXB1 Transcription Factors
Tumor Microenvironment

Substances

SOX2 protein, human
SOXB1 Transcription Factors