Recent progress in broadly neutralizing antibodies to HIV

Nat Immunol. 2018 Nov;19(11):1179-1188. doi: 10.1038/s41590-018-0235-7. Epub 2018 Oct 17.


In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characterization of novel bnAbs, recent data on the effects of bnAbs in vivo in humans and animal models, and the importance of both kinds of data for the application of Abs to prophylaxis and therapy and to guide vaccine design. We seek to place newly discovered bnAbs in the context of existing bnAbs, and we explore the various characteristics of the antibodies that are most desirable for different applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS Vaccines / immunology
  • Animals
  • Antibodies, Neutralizing / immunology*
  • HIV Antibodies / immunology*
  • HIV Infections / immunology*
  • Humans


  • AIDS Vaccines
  • Antibodies, Neutralizing
  • HIV Antibodies