Programmed longevity, youthspan, and juventology

Aging Cell. 2019 Feb;18(1):e12843. doi: 10.1111/acel.12843. Epub 2018 Oct 17.


The identification of conserved genes and pathways that regulate lifespan but also healthspan has resulted in an improved understanding of the link between nutrients, signal transduction proteins, and aging but has also provided evidence for the existence of multiple "longevity programs," which are selected based on the availability of nutrients. Periodic fasting and other dietary restrictions can promote entry into a long-lasting longevity program characterized by cellular protection and optimal function but can also activate regenerative processes that lead to rejuvenation, which are independent of the aging rate preceding the restricted period. Thus, a "juventology"-based strategy can complement the traditional gerontology approach by focusing not on aging but on the longevity program affecting the life history period in which mortality is very low and organisms remain youthful, healthy, and fully functional.

Keywords: Juventology; Longevity; aging; gerontology; healthspan; youthspan.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Caloric Restriction*
  • Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
  • Diet, Protein-Restricted*
  • Fasting / physiology*
  • Free Radicals / adverse effects
  • Growth Hormone / antagonists & inhibitors
  • Humans
  • Insulin-Like Growth Factor I / antagonists & inhibitors
  • Life Expectancy*
  • Longevity / genetics*
  • Mice
  • Middle Aged
  • Nutrients / physiology
  • Rejuvenation / physiology*
  • Ribosomal Protein S6 Kinases / antagonists & inhibitors
  • Saccharomyces cerevisiae / metabolism
  • Sirolimus / pharmacology
  • TOR Serine-Threonine Kinases / antagonists & inhibitors
  • Young Adult


  • Free Radicals
  • Insulin-Like Growth Factor I
  • Growth Hormone
  • Ribosomal Protein S6 Kinases
  • TOR Serine-Threonine Kinases
  • Cyclic AMP-Dependent Protein Kinases
  • Sirolimus