All Foot and Mouth Disease Virus Serotypes Initiate Protein Synthesis at Two Separate AUGs

Nucleic Acids Res. 1987 Apr 24;15(8):3305-15. doi: 10.1093/nar/15.8.3305.


Translation of the foot and mouth disease virus genome in vitro and in vivo indicated that all seven serotypes initiate protein synthesis at two separate AUGs. Sequence analysis of the region surrounding these AUGs has shown that the efficiency with which the initiating AUG is recognized is dependent on the flanking nucleotides. However, in vitro, the major factor determining which AUG is used is the concentration of Mg2+.

MeSH terms

  • Aphthovirus / classification
  • Aphthovirus / genetics*
  • Base Sequence
  • Codon*
  • Magnesium / physiology
  • Protein Biosynthesis*
  • RNA, Messenger*
  • RNA, Viral / genetics
  • Viral Proteins / genetics


  • Codon
  • RNA, Messenger
  • RNA, Viral
  • Viral Proteins
  • Magnesium