Biomimetic cofactors and methods for their recycling

Ioannis Zachos; Claudia Nowak; Volker Sieber

doi:10.1016/j.cbpa.2018.10.003

Biomimetic cofactors and methods for their recycling

Curr Opin Chem Biol. 2019 Apr:49:59-66. doi: 10.1016/j.cbpa.2018.10.003. Epub 2018 Oct 16.

Authors

Ioannis Zachos¹, Claudia Nowak², Volker Sieber³

Affiliations

¹ Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany.
² Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany; Current address: Dr. Ebeling & Assoc. GmbH, Hamburg, Germany.
³ Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany; Catalysis Research Center, Technical University of Munich, Garching, Germany; Fraunhofer Institute of InterfacialBiotechnology (IGB), Bio-, Electro- and Chemo Catalysis (BioCat) Branch, Straubing, Germany; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Qld, Australia. Electronic address: sieber@tum.de.

PMID: 30336443
DOI: 10.1016/j.cbpa.2018.10.003

Abstract

Nicotinamide cofactor biomimetics (NCBs) belong to a class of compounds that, as the name suggests, mimic the structures and functions of natural nicotinamide cofactors, namely nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate and their corresponding reduced forms. The first set of NCBs was discovered in the 1930s; these were initially used to study the chemical properties of this class of cofactors as well as understand nicotinamide binding of oxidoreductases. Since then, various NCBs, enzymes, and recycling systems have evolved and lately, new NCBs have been developed and used to run biocatalytic reactions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocatalysis*
Biomimetics*
NAD / metabolism*
Niacinamide / metabolism*

Substances

NAD
Niacinamide