Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer Disease

Roula Al-Dahhak; Rita Khoury; Erum Qazi; George T Grossberg

doi:10.1016/j.cger.2018.06.008

Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer Disease

Clin Geriatr Med. 2018 Nov;34(4):617-635. doi: 10.1016/j.cger.2018.06.008. Epub 2018 Aug 21.

Authors

Roula Al-Dahhak¹, Rita Khoury², Erum Qazi², George T Grossberg²

Affiliations

¹ Department of Neurology, Saint Louis University, 1438 South Grand Boulevard, Suite 105, St Louis, MO 63104, USA. Electronic address: roula.aldahhak@health.slu.edu.
² Department of Psychiatry and Behavioral Neuroscience, Saint Louis University, 1438 South Grand Boulevard, St Louis, MO 63104, USA.

PMID: 30336991
DOI: 10.1016/j.cger.2018.06.008

Abstract

Traumatic brain injury (TBI) is a major health and economic burden. With increasing aging population, this issue is expected to continue to rise. Neurodegenerative disorders are more common with aging population in general regardless of history of TBI. Recent evidence continues to support a relation between a TBI and neurocognitive decline later in life (such as in athletes and military). This article summarizes the pathologic and clinical effects of TBI (regardless of severity) on the later development of dementia in individuals 65 years or older.

Keywords: Chronic traumatic encephalopathy; Concussion; Dementia; Neurodegenerative disorders; Traumatic brain injury.

Publication types

Review

MeSH terms

Aged
Alzheimer Disease* / diagnosis
Alzheimer Disease* / etiology
Brain Injuries, Traumatic* / classification
Brain Injuries, Traumatic* / complications
Brain Injuries, Traumatic* / diagnosis
Brain Injuries, Traumatic* / psychology
Cognitive Dysfunction* / diagnosis
Cognitive Dysfunction* / etiology
Humans
Neurodegenerative Diseases* / diagnosis
Neurodegenerative Diseases* / etiology
Prognosis
Psychopathology
Severity of Illness Index