Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer Disease

Clin Geriatr Med. 2018 Nov;34(4):617-635. doi: 10.1016/j.cger.2018.06.008. Epub 2018 Aug 21.


Traumatic brain injury (TBI) is a major health and economic burden. With increasing aging population, this issue is expected to continue to rise. Neurodegenerative disorders are more common with aging population in general regardless of history of TBI. Recent evidence continues to support a relation between a TBI and neurocognitive decline later in life (such as in athletes and military). This article summarizes the pathologic and clinical effects of TBI (regardless of severity) on the later development of dementia in individuals 65 years or older.

Keywords: Chronic traumatic encephalopathy; Concussion; Dementia; Neurodegenerative disorders; Traumatic brain injury.

Publication types

  • Review

MeSH terms

  • Aged
  • Alzheimer Disease* / diagnosis
  • Alzheimer Disease* / etiology
  • Brain Injuries, Traumatic* / classification
  • Brain Injuries, Traumatic* / complications
  • Brain Injuries, Traumatic* / diagnosis
  • Brain Injuries, Traumatic* / psychology
  • Cognitive Dysfunction* / diagnosis
  • Cognitive Dysfunction* / etiology
  • Humans
  • Neurodegenerative Diseases* / diagnosis
  • Neurodegenerative Diseases* / etiology
  • Prognosis
  • Psychopathology
  • Severity of Illness Index