New Insights into the Pathogenesis and Treatment of Malnutrition

Gastroenterol Clin North Am. 2018 Dec;47(4):813-827. doi: 10.1016/j.gtc.2018.07.007. Epub 2018 Sep 28.


The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

Keywords: Epigenetics; Immune deficiency; Intestinal microbiota; Perinatal; Prenatal; Protein deficiency; Therapeutic foods; Undernutrition.

Publication types

  • Review

MeSH terms

  • Humans
  • Malnutrition / etiology*
  • Malnutrition / pathology
  • Malnutrition / therapy*