Infantile Colic: New Insights into an Old Problem

Gastroenterol Clin North Am. 2018 Dec;47(4):829-844. doi: 10.1016/j.gtc.2018.07.008. Epub 2018 Sep 28.


Infant colic is a characteristic group of behaviors seen in young infants. The most prominent feature is prolonged crying. Additional characteristics, including clenching of the fists and flexion of the hips, have led to the suggestion that these behaviors are related to abdominal discomfort. In this article, we show emerging evidence to support the concept that infant colic could represent gut inflammation and microbial dysbiosis that impacts brain function and even brain development.

Keywords: Barr diary; Crying; Infant; Microbiome; Neutropenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Colic / diagnosis
  • Colic / etiology*
  • Colic / therapy*
  • Crying
  • Humans
  • Infant
  • Infant, Newborn