Advances in Pediatric Fatty Liver Disease: Pathogenesis, Diagnosis, and Treatment

Hayley A Braun; Sarah A Faasse; Miriam B Vos

doi:10.1016/j.gtc.2018.07.016

Advances in Pediatric Fatty Liver Disease: Pathogenesis, Diagnosis, and Treatment

Gastroenterol Clin North Am. 2018 Dec;47(4):949-968. doi: 10.1016/j.gtc.2018.07.016. Epub 2018 Sep 28.

Authors

Hayley A Braun¹, Sarah A Faasse², Miriam B Vos²

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive North East, Atlanta, GA 30322, USA. Electronic address: Hayley.Braun@emory.edu.
² Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive North East, Atlanta, GA 30322, USA; Division of Gastroenterology, Hepatology, and Nutrition, Children's Healthcare of Atlanta, 1405 Clifton Road, Atlanta, GA 30329, USA.

PMID: 30337043
DOI: 10.1016/j.gtc.2018.07.016

Abstract

Pediatric nonalcoholic fatty liver disease is an increasingly prevalent disease, but its pathophysiology is not fully elucidated, diagnosis is difficult and invasive, and therapeutic options are limited. This article addresses the recent advancements made in understanding the pathophysiology of nonalcoholic fatty liver disease, the development of less invasive diagnostic modalities, and emerging therapeutic options, including ongoing clinical trials in children.

Keywords: Diagnosis; Pediatric NAFLD; Review; Treatment; Type II diabetes.

Publication types

Review

MeSH terms

Child
Humans
Non-alcoholic Fatty Liver Disease / diagnosis
Non-alcoholic Fatty Liver Disease / etiology*
Non-alcoholic Fatty Liver Disease / therapy*