Nucleotide sequence and genome organization of human papillomavirus type 5

Virology. 1987 May;158(1):251-4. doi: 10.1016/0042-6822(87)90263-7.


Human papillomavirus (HPV) type 5 is associated with benign and malignant lesions of the disease epidermodysplasia verruciformis (EV). Because of the strong correlation between the presence of HPV-5 and malignant progression in these patients, we have elucidated the nucleotide sequence of the HPV-5 genome. The size of the HPV-5 genome is 7746 nucleotides and its organization is similar to that of other papillomaviruses. The HPV-5 genome exhibits extensive sequence homology with another EV-associated papillomavirus, HPV-8, although HPV-5 appears to contain at least one additional open reading frame.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • DNA, Viral / genetics*
  • Genes, Viral*
  • Humans
  • Papillomaviridae / genetics*
  • Sequence Homology, Nucleic Acid


  • DNA, Viral

Associated data

  • GENBANK/M17463