Quantitative Fundus Autofluorescence in Non-Neovascular Age-Related Macular Degeneration

Ophthalmic Surg Lasers Imaging Retina. 2018 Oct 15;49(10):S34-S42. doi: 10.3928/23258160-20180814-06.


Background and objective: To use quantitative fundus autofluorescence (qAF) to analyze different stages of non-neovascular age-related macular degeneration (AMD).

Patients and methods: In this cohort study, 38 pseudophakic patients and 36 age-matched controls participated. We performed near-infrared, spectral-domain optical coherence tomography and qAF imaging on 31 pseudophakic eyes and controls of participants older than 60 years with non-neovascular AMD phenotypes using the Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany).

Results: The patients included in this study had a mean age of 83.9 years, and 35.7% patients were men. Mean qAF was higher in control participants than in all patients with AMD (P < .001). According to non-neovascular AMD phenotype, mean qAF levels were significantly lower in eyes with subretinal drusenoid deposits than in control eyes (P < .05). The lowest mean qAF was in patients with geographic atrophy.

Conclusion: Quantitative fundus autofluorescence of non-neovascular AMD decreases from normal to early to late AMD, suggesting that loss of lipofuscin fluorophores, not increase, signifies AMD progression. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:S34-S42.].

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Disease Progression
  • Female
  • Fluorescein Angiography / methods*
  • Fundus Oculi
  • Humans
  • Macula Lutea / pathology*
  • Macular Degeneration / diagnosis*
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Retrospective Studies
  • Tomography, Optical Coherence / methods*
  • Visual Acuity