Nerve hydrodissection for carpal tunnel syndrome: A prospective, randomized, double-blind, controlled trial

Muscle Nerve. 2019 Feb;59(2):174-180. doi: 10.1002/mus.26358. Epub 2018 Dec 4.


Introduction: In this study we explored the efficacy of nerve hydrodissection for mild-to-moderate carpal tunnel syndrome (CTS).

Methods: Thirty-four participants were randomly assigned to an intervention group or a control group. One 5-ml dose of normal saline was injected into the intracarpal and subcutaneous regions in subjects of both groups, respectively. The primary outcome measure was the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) score. Secondary outcomes were cross-sectional area of the median nerve and electrophysiological studies. Assessments were performed before the injection and at 1, 2, 3, and 6 months postintervention.

Results: Compared with the control group, the intervention group showed significantly greater improvement at the second and third posttreatment months according to BCTQ severity score and at all time-points for cross-sectional area of the median nerve (P < 0.01).

Discussion: Our study demonstrates the therapeutic effects of nerve hydrodissection for mild-to-moderate CTS. Muscle Nerve 59:174-180, 2019.

Trial registration: NCT02991001.

Keywords: carpal tunnel syndrome; entrapment; nerve hydrodissection; perineural injection; ultrasound-guided.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carpal Tunnel Syndrome / diagnostic imaging
  • Carpal Tunnel Syndrome / drug therapy*
  • Cross-Sectional Studies
  • Double-Blind Method
  • Electric Stimulation
  • Female
  • Humans
  • Male
  • Median Nerve / diagnostic imaging
  • Median Nerve / drug effects*
  • Median Nerve / physiology*
  • Middle Aged
  • Neural Conduction / drug effects
  • Pain Measurement
  • Prospective Studies
  • Saline Solution / therapeutic use*
  • Statistics, Nonparametric
  • Surveys and Questionnaires
  • Time Factors
  • Treatment Outcome
  • Ultrasonography, Interventional
  • Young Adult


  • Saline Solution

Associated data