Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro

Braz J Infect Dis. 2018 Sep-Oct;22(5):412-417. doi: 10.1016/j.bjid.2018.08.005. Epub 2018 Oct 16.


Background: Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women.

Aim: To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil.

Methods: A cohort study. Epidemiological, clinical, and laboratory data were compared between perinatally (PHIV) and behaviorally HIV-infected (BHIV) pregnant youth with the primary aim to study pregnancy outcomes in the PHIV group and compare with outcomes to BHIV group.

Results: Thirty-two pregnancies occurred in PHIV group, and 595 in BHIV group. A total of seven (22%) PHIV women and 64 (11%) BHIV women had a premature delivery (p=0.04), however, when adjusting for younger age at pregnancy, and antiretroviral therapy initiation in 1st trimester of pregnancy (OR=18.66, 95%CI=5.52-63.14), the difference was no longer significant. No cases of mother-to-child HIV transmission (MTCT) were observed in the PHIV group while there was a 2% MTCT rate in BHIV group.

Conclusion: Pregnancy among PHIV was as safe as among BHIV. The differences between those groups were probably related to treatment and prolonged care in the first group.

Keywords: Combined antiretroviral treatment; Mother-to-child transmission; Perinatal HIV; Pregnancy.

MeSH terms

  • Adolescent
  • Age Factors
  • Antiretroviral Therapy, Highly Active / statistics & numerical data
  • Brazil / epidemiology
  • CD4 Lymphocyte Count
  • Female
  • HIV Infections / epidemiology*
  • HIV Infections / transmission
  • Humans
  • Infectious Disease Transmission, Vertical / statistics & numerical data
  • Multivariate Analysis
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology*
  • Pregnancy Outcome / epidemiology*
  • Prospective Studies
  • Risk Factors
  • Unsafe Sex
  • Viral Load
  • Young Adult