Fulminant mulch pneumonitis in a previously healthy child

Arch Pediatr. 2018 Nov;25(8):495-496. doi: 10.1016/j.arcped.2018.09.003. Epub 2018 Oct 16.

Abstract

Chronic granulomatous disease (CGD) is associated with multiple and recurrent infections. In patients with CGD, invasive pulmonary infection with aspergillus species remains the greatest cause of mortality. Acute fulminant presentations of fungal pneumonia are catastrophic. It is a medical emergency, and currently the treatment is based on association of corticosteroids and antifungal therapy. We describe the case of an 11-year-old boy, with late initial presentation of CGD, which was revealed by fulminant aspergillus pneumonia. He was successfully treated with an association of high doses of steroids and voriconazole.

Keywords: Child; Chronic granulomatous disease; Fulminant mulch pneumonitis; Management.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Child
  • Diagnosis, Differential
  • Glucocorticoids / therapeutic use
  • Granulomatous Disease, Chronic / complications*
  • Granulomatous Disease, Chronic / drug therapy
  • Humans
  • Male
  • Pneumonia / complications*
  • Pneumonia / drug therapy
  • Pulmonary Aspergillosis / complications*
  • Pulmonary Aspergillosis / drug therapy
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Glucocorticoids
  • Voriconazole