Low-frequency positive pressure ventilation with extracorporeal carbon dioxide removal (LFPPV-ECCO2R): an experimental study

Anesth Analg. 1978 Jul-Aug;57(4):470-7. doi: 10.1213/00000539-197807000-00018.


We describe a new form of mechanical pulmonary ventilation, low-frequency positive pressure ventilation with extracorporeal CO2 removal (LEPPV-ECCO2R). In a series of animal studies the rate of mechanical ventilation was 0.66, 1, 2, and 4 min-1 at a tidal volume of 3, 10, and 15 ml kg-1. We were able to maintain normal blood gases and normal lung volumes and lung mechanics even at the lowest ventilator rate with tidal volumes of 10 or 15 ml kg-1. Each experiment lasted 7 hours. Our data suggest a possible new dimension in the management of a difficult patient on mechanical pulmonary ventilation.

MeSH terms

  • Animals
  • Carbon Dioxide / blood
  • Carbon Dioxide / metabolism*
  • Hydrogen-Ion Concentration
  • Models, Biological*
  • Oxygen / blood
  • Oxygen Inhalation Therapy / methods
  • Positive-Pressure Respiration / methods*
  • Sheep
  • Tidal Volume
  • Ventilation-Perfusion Ratio


  • Carbon Dioxide
  • Oxygen