Esophageal Lichen Planus Is Associated With a Significant Increase in Risk of Squamous Cell Carcinoma

Clin Gastroenterol Hepatol. 2019 Aug;17(9):1902-1903.e1. doi: 10.1016/j.cgh.2018.10.018. Epub 2018 Oct 17.

Abstract

Esophageal lichen planus (ELP) is a chronic inflammatory process characterized by apoptotic activity of cytotoxic CD8+ T cells on basal keratinocytes as well as regulatory and helper T cells.1-3 Due to chronic inflammation, malignant transformation may be a concern and has been documented in case reports.4,5 We describe the occurrence of esophageal cancer in ELP patients from a large tertiary patient population.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Chemotherapy, Adjuvant
  • Deglutition Disorders
  • Disease Progression
  • Endoscopic Mucosal Resection
  • Endoscopy, Digestive System
  • Esophageal Diseases / drug therapy
  • Esophageal Diseases / epidemiology
  • Esophageal Diseases / pathology
  • Esophageal Neoplasms / epidemiology*
  • Esophageal Neoplasms / physiopathology
  • Esophageal Neoplasms / therapy
  • Esophageal Squamous Cell Carcinoma / epidemiology*
  • Esophageal Squamous Cell Carcinoma / physiopathology
  • Esophageal Squamous Cell Carcinoma / therapy
  • Esophagectomy
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lichen Planus / drug therapy
  • Lichen Planus / epidemiology*
  • Lichen Planus / pathology
  • Male
  • Middle Aged
  • Radiotherapy, Adjuvant
  • Risk Factors

Substances

  • Glucocorticoids
  • Immunosuppressive Agents