Glutathione as a Marker for Human Disease

Adv Clin Chem. 2018:87:141-159. doi: 10.1016/bs.acc.2018.07.004. Epub 2018 Aug 23.


Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damage and thus as expected, GSH imbalance is observed in a wide range of pathological conditions including tuberculosis (TB), HIV, diabetes, cancer, and aging. Consequently, it is not surprising that GSH has attracted the attention of biological researchers and pharmacologists alike as a possible target for medical intervention. Here, we discuss the role GSH plays amongst these pathological conditions to illuminate how it can be used as a marker for human disease.

Keywords: Ageing; Cancer; Diabetes; Glutathione; HIV; Tuberculosis.

Publication types

  • Review

MeSH terms

  • Aging
  • Animals
  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Diabetes Mellitus / metabolism
  • Glutamate-Cysteine Ligase / metabolism
  • Glutathione / analysis
  • Glutathione / metabolism*
  • HIV Infections / metabolism
  • Humans
  • Neoplasms / metabolism
  • Oxidative Stress*
  • Tuberculosis / metabolism
  • Vitamin D / metabolism


  • Biomarkers
  • Vitamin D
  • Glutamate-Cysteine Ligase
  • Glutathione