Umbilical Cord Tissue and Meconium May Not Be Equivalent for Confirming in Utero Substance Exposure

J Pediatr. 2019 Feb;205:277-280. doi: 10.1016/j.jpeds.2018.09.046. Epub 2018 Oct 17.


In a retrospective study of 501 neonates with potential in utero substance exposure, the drug detection performance of a commercially available umbilical cord tissue toxicology test was evaluated against a commercially available gold standard meconium toxicology test. Drugs detected in paired meconium and umbilical cord tissue samples were often discordant.

Keywords: drug screening; in utero drug exposure; meconium; toxicology; umbilical cord tissue.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Female
  • Follow-Up Studies
  • Humans
  • Illicit Drugs / analysis*
  • Illicit Drugs / toxicity
  • Infant, Newborn
  • Male
  • Maternal-Fetal Exchange / physiology*
  • Meconium / chemistry*
  • Meconium / cytology
  • Pregnancy
  • Prenatal Exposure Delayed Effects / diagnosis*
  • Prenatal Exposure Delayed Effects / metabolism
  • Retrospective Studies
  • Substance Abuse Detection / methods*
  • Umbilical Cord / chemistry*
  • Umbilical Cord / cytology


  • Illicit Drugs