The master regulator FUBP1: its emerging role in normal cell function and malignant development

Cell Mol Life Sci. 2019 Jan;76(2):259-281. doi: 10.1007/s00018-018-2933-6. Epub 2018 Oct 20.


The human Far Upstream Element (FUSE) Binding Protein 1 (FUBP1) is a multifunctional DNA- and RNA-binding protein involved in diverse cellular processes. FUBP1 is a master regulator of transcription, translation, and RNA splicing. FUBP1 has been identified as a potent pro-proliferative and anti-apoptotic factor by modulation of complex networks. FUBP1 is also described either as an oncoprotein or a tumor suppressor. Especially, FUBP1 overexpression is observed in a growing number of cancer and leads to a deregulation of targets that includes the fine-tuned MYC oncogene. Moreover, recent loss-of-function analyses of FUBP1 establish its essential functions in hematopoietic stem cell maintenance and survival. Therefore, FUBP1 appears as an emerging suspect in hematologic disorders in addition to solid tumors. The scope of the present review is to describe the advances in our understanding of the molecular basis of FUBP1 functions in normal cells and carcinogenesis. We also delineate the recent progresses in the understanding of the master role of FUBP1 in normal and pathological hematopoiesis. We conclude that FUBP1 is not only worth studying biologically but is also of clinical relevance through its pivotal role in regulating multiple cellular processes and its involvement in oncogenesis.

Keywords: FIR; KH domain; Leukemia; P21; P53; c-KIT.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Cell Transformation, Neoplastic / genetics
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclin-Dependent Kinases / metabolism
  • DNA / chemistry
  • DNA / metabolism
  • DNA Helicases / genetics
  • DNA Helicases / metabolism*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Homeodomain Proteins / metabolism
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Proto-Oncogene Proteins c-myc / metabolism
  • RNA-Binding Proteins
  • Ubiquitin-Specific Proteases / metabolism


  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • FUBP1 protein, human
  • Homeodomain Proteins
  • Proto-Oncogene Proteins c-myc
  • RNA-Binding Proteins
  • DNA
  • Cyclin-Dependent Kinases
  • USP29 protein, human
  • Ubiquitin-Specific Proteases
  • DNA Helicases