Cardiac Glucolipotoxicity and Cardiovascular Outcomes

Medicina (Kaunas). 2018 Oct 11;54(5):70. doi: 10.3390/medicina54050070.


Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function.

Keywords: bioenergetics; cardiac development; diabetes; fatty acids; glucose transport; hyperglycemia.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / metabolism*
  • Fatty Acids / metabolism*
  • Glucose / metabolism*
  • Glucose Metabolism Disorders / complications
  • Glucose Metabolism Disorders / metabolism*
  • Heart / growth & development*
  • Humans
  • Insulin / metabolism*
  • Myocardium / metabolism*
  • Obesity / complications
  • Obesity / metabolism
  • Signal Transduction


  • Fatty Acids
  • Insulin
  • Glucose