[Joint amplification of c-myc and c-Ha-ras oncogenes in human breast and thyroid cancer cells]

Eksp Onkol. 1987;9(2):15-7.
[Article in Russian]


Both c-myc and c-Ha-ras 1 oncogenes amplification and enhanced expression were revealed in some human mammary and thyroid carcinomas by the molecular genetic analysis. Amplification proves to be a second possible molecular mechanism of the ras family protooncogene activation besides a point mutation. The coexistence of c-myc and c-Ha-ras 1 in some human primary carcinomas suggests a multistep process of carcinogenesis.

Publication types

  • English Abstract

MeSH terms

  • Breast Neoplasms / genetics*
  • DNA Restriction Enzymes
  • DNA, Neoplasm / genetics
  • Gene Amplification*
  • Humans
  • Nucleic Acid Hybridization
  • Proto-Oncogenes*
  • Thyroid Neoplasms / genetics*


  • DNA, Neoplasm
  • DNA Restriction Enzymes