Milk Powder Co-Supplemented with Inulin and Resistant Dextrin Improves Glycemic Control and Insulin Resistance in Elderly Type 2 Diabetes Mellitus: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial

Mol Nutr Food Res. 2018 Dec;62(24):e1800865. doi: 10.1002/mnfr.201800865. Epub 2018 Dec 3.


Scope: The objective of the present study is to evaluate the effects of milk powder co-supplemented with inulin and resistant dextrin (MPCIR) on elderly patients with type 2 diabetes mellitus (T2DM).

Methods and results: A randomized, double-blind, placebo-controlled clinical trial is carried out among elderly T2DM patients. The subjects recruited from the community are randomly assigned to either the MPCIR group or placebo group for 12 weeks intervention. Each group receives 45 g milk powder with or without inulin and resistant dextrin. Anthropometric and metabolic variables are measured. For the MPCIR group, systolic blood pressure (BP) and diastolic BP are reduced significantly by 5.45 and 4.56 mm Hg (p < 0.001, vs placebo group), respectively. Compared with the placebo group, the fasting and 2-h postprandial plasma glucose levels, glycosylated serum protein, and insulin resistance index of the MPCIR group are significantly decreased by 0.96 mmol L-1 , 1.47 mmol L-1 , 16.33 μmol L-1 , and 0.65 respectively (p < 0.001). The MPCIR group shows an increase by 7.09 μIU mL-1 and 20.43 in 2-h postprandial insulin (p = 0.016) and β-cell function index (p < 0.001), respectively.

Conclusion: MPCIR supplementation helps to improve glycemic control, insulin resistance, and blood pressure.

Keywords: fiber; insulin; inulin; resistant dextrin; type 2 diabetes mellitus.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Blood Glucose
  • Blood Pressure / drug effects
  • Dextrins / pharmacology*
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Dietary Supplements
  • Humans
  • Insulin Resistance
  • Inulin / adverse effects
  • Inulin / pharmacology*
  • Lipid Metabolism / drug effects
  • Middle Aged
  • Milk / chemistry*
  • Placebos
  • Treatment Outcome


  • Blood Glucose
  • Dextrins
  • Placebos
  • Inulin