HIF-1α drives cyst growth in advanced stages of autosomal dominant polycystic kidney disease

Kidney Int. 2018 Nov;94(5):849-851. doi: 10.1016/j.kint.2018.07.012.

Abstract

Progressive cyst expansion in autosomal-dominant polycystic kidney disease has been shown to cause regional hypoxia in cystic and pericystic tissue. This results in up-regulation of hypoxia-inducible transcription factor (HIF) 1α in cyst epithelial cells. However, the functional impact of HIF-1α in cystic kidney disease was unknown. A new study has shown that HIF-1α promotes cyst progression in a mouse model of autosomal-dominant polycystic kidney disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cysts
  • Epithelial Cells
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Mice
  • Polycystic Kidney Diseases*
  • Polycystic Kidney, Autosomal Dominant*

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit