A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory

Nat Neurosci. 2018 Nov;21(11):1515-1519. doi: 10.1038/s41593-018-0248-4. Epub 2018 Oct 22.


The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amygdala / physiology*
  • Animals
  • Conditioning, Classical / physiology*
  • Extinction, Psychological / physiology
  • Fear / physiology*
  • Memory / physiology*
  • Mental Recall / physiology
  • Mice
  • Neural Pathways / physiology
  • Neurons / physiology
  • Zona Incerta / physiology*