Aphrodisiac properties of hydro-alcoholic extract of Cassia auriculata flower in male rats

Andrologia. 2019 Mar;51(2):e13180. doi: 10.1111/and.13180. Epub 2018 Oct 22.

Abstract

Cassia auriculata is a commonly found plant in Asia, widely used in Ayurveda and Siddha medicines as a tonic, astringent and in general for diabetes. Herbal tea made from this plant has been marketed as a product for restoring sexual vitality, to increase sperm count and counteract ejaculatory disorders. However, the scientific evidences are scarce to prove this concept. Here, we examined the effect of hydro-alcoholic extract obtained from C. auriculata flower upon the expression of male Wistar albino rat's sexual behaviour. Sildenafil was used as a positive control. Penile erection index (PEI), mount latency (ML), intromission latency (IL), ejaculation latency (EL), mounting frequency (MF), intromission frequency (IF), ejaculation frequency (EF) and post-ejaculatory interval (PEjI) were recorded for days 0, 7, 14 and 28 and also after the withdrawal of the treatment on days 7 and 15. Significant reduction in ML, IL and PEjI, and increment in EL, PEI, MF, IF and EF were observed (p < 0.05, <0.01). However, neither extract nor sildenafil sustains the effect after withdrawal of the treatment. The present finding demonstrates the aphrodisiac potential of hydro-alcoholic extract of C. auriculata flower in vivo and lends support to the traditional utilisation as a sexual stimulating agent.

Keywords: Cassia auriculata; PDE5; animal model; erectile dysfunction.

MeSH terms

  • Animals
  • Aphrodisiacs / pharmacology*
  • Cassia*
  • Ejaculation / drug effects*
  • Male
  • Penile Erection / drug effects*
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Sexual Behavior, Animal / drug effects*

Substances

  • Aphrodisiacs
  • Plant Extracts