[Neurological Pathology Associated With Vitamin B Group Deficiency: Thiamine, Folate and Cobalamin]

Nutr Hosp. 2018 Sep 7;35(Spec No6):54-59. doi: 10.20960/nh.2289.
[Article in Spanish]

Abstract

The "fragility" of the nervous system, especially concerning to its nutrition and metabolism, explains why vitamin deficits are an important cause of neurological pathology. Some deficiency diseases, which can be very severe and irreversible, are still present in our environment; diagnosis, which must be early so as not to delay treatment, can be difficult if we do not have them in mind. In this review we address the most relevant neurological diseases associated with thiamine, folate and cobalamin deficiency, and we focus especially combined subacute degeneration and Wernicke-Korsakoff syndrome.

La “fragilidad” del sistema nervioso, en especial en lo referente a su nutrición y metabolismo, explica que los déficits vitamínicos sean una causa importante de patología neurológica. Algunas enfermedades carenciales, que pueden ser muy graves e irreversibles, aún se presentan en nuestro entorno. Su diagnóstico, que debe ser precoz para no retrasar el tratamiento, puede ser complicado si no las tenemos en mente. En esta revisión abordamos las enfermedades neurológicas más relevantes asociadas al déficit de tiamina, folatos y cobalamina, deteniéndonos especialmenteen la degeneración combinada subaguda y el síndrome de Wernicke-Korsakoff.

Publication types

  • Review

MeSH terms

  • Folic Acid Deficiency / complications
  • Folic Acid Deficiency / pathology
  • Humans
  • Nervous System Diseases / etiology*
  • Nervous System Diseases / pathology*
  • Thiamine Deficiency / complications
  • Thiamine Deficiency / pathology
  • Vitamin B 12 Deficiency / complications
  • Vitamin B 12 Deficiency / pathology
  • Vitamin B Complex
  • Vitamin B Deficiency / complications
  • Vitamin B Deficiency / pathology*

Substances

  • Vitamin B Complex