Characterization of a colistin-resistant Salmonella enterica 4,[5],12:i:- harbouring mcr-3.2 on a variant IncHI-2 plasmid identified in Canada

J Med Microbiol. 2018 Dec;67(12):1673-1675. doi: 10.1099/jmm.0.000854. Epub 2018 Oct 23.

Abstract

We have identified a Salmonella enterica serotype 4,[5],12:i:- containing a mcr-3.2 in a patient who travelled to Thailand 1 month prior to the identification of it in Canada. The isolate was multidrug resistant, but remained susceptible to the carbapenems, amikacin and piperacillin/tazobactam. The mcr-3.2 was carried on a 261 Kb variant of the IncHI2 pWJ1. This report provides further evidence of the emergence of a ST34 colistin-resistant clone.

Keywords: Salmonella 4,[5],12:i:-; mcr-3.2; mobile colistin resistance.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Canada / epidemiology
  • Colistin / pharmacology*
  • Drug Resistance, Multiple, Bacterial*
  • Genetic Variation
  • Humans
  • Salmonella Infections / drug therapy
  • Salmonella Infections / epidemiology
  • Salmonella Infections / microbiology*
  • Salmonella enterica / drug effects*
  • Salmonella enterica / genetics*
  • Thailand / epidemiology
  • Travel

Substances

  • Anti-Bacterial Agents
  • Colistin