A Proteomic Map to Navigate Subcellular Reorganization in Fatty Liver Disease

Dev Cell. 2018 Oct 22;47(2):139-141. doi: 10.1016/j.devcel.2018.10.006.

Abstract

In a tour de force in this issue of Developmental Cell, Krahmer et al. leverage proteomic platforms to reveal subcellular proteome dynamics during development of nonalcoholic fatty liver disease. Their findings uncover a remarkable degree of subcellular reorganization, alterations in protein localization, and remodeling of organelle contact sites.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Diet
  • Fatty Liver*
  • Humans
  • Organelles
  • Proteome
  • Proteomics*

Substances

  • Proteome