Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec;7(12):1275-1279.
doi: 10.1530/EC-18-0191.

Serum Vitamin D Deficiency in Children and Adolescents Is Associated With Type 1 Diabetes Mellitus

Free PMC article

Serum Vitamin D Deficiency in Children and Adolescents Is Associated With Type 1 Diabetes Mellitus

Changwei Liu et al. Endocr Connect. .
Free PMC article


Background: To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM).

Methods: A case-control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls.

Results: The mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05).

Conclusion: Vitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children.

Keywords: insufficient; type 1 diabetes mellitus; vitamin D.


Figure 1
Figure 1
Linear correlation between serum 25OHD level and hemoglobin A1c in established T1DM.

Similar articles

See all similar articles

Cited by 2 articles


    1. Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. Pediatric Diabetes 2009. 10 (Supplement 12) 3–12. (10.1111/j.1399-5448.2009.00568.x) - DOI - PubMed
    1. Weng J, Zhou Z, Guo L, Zhu D, Ji L, Luo X, Mu Y, Jia W. Incidence of type 1 diabetes in China, 2010-13: population based study. BMJ 2018. 360 j5295 (10.1136/bmj.j5295) - DOI - PMC - PubMed
    1. Wu H, Zhong J, Yu M, Wang H, Gong W, Pan J, Fei F, Wang M, Yang L, Hu R. Incidence and time trends of type 2 diabetes mellitus in youth aged 5-19 years: a population-based registry in Zhejiang, China, 2007 to 2013. BMC Pediatrics 2017. 17 85 (10.1186/s12887-017-0834-8) - DOI - PMC - PubMed
    1. Itoh A, Ridgway WM. Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes. ImmunoTargets and Therapy 2017. 6 31–38. (10.2147/ITT.S117264) - DOI - PMC - PubMed
    1. Muñoz GA, Kutmon M, Eijssen L, Hewison M, Evelo CT, Coort SL. Pathway analysis of transcriptomic data shows immunometabolic effects of vitamin D. Journal of Molecular Endocrinology 2018. 60 95–108. (10.1530/JME-17-0186) - DOI - PMC - PubMed

LinkOut - more resources