Safe CRISPR: Challenges and Possible Solutions

Trends Biotechnol. 2019 Apr;37(4):389-401. doi: 10.1016/j.tibtech.2018.09.010. Epub 2018 Oct 21.


Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

Keywords: CRISPR; biosafety; gene drives; gene therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomedical Research / trends
  • Clustered Regularly Interspaced Short Palindromic Repeats*
  • Gene Editing*
  • Genetic Therapy / adverse effects
  • Genetic Therapy / methods*
  • Humans
  • Molecular Targeted Therapy / adverse effects
  • Molecular Targeted Therapy / methods*